Such a diverse and sensitive eco-region as Karst needs to be managed with special attention and consideration of its natural and cultural resources. Land cover is an important indicator, which enables the analysis of their condition and development monitoring. Advanced satellite images classification represents an accurate and cost-effective alternative to the classical techniques of land cover mapping. The methods used to produce a reliable land cover map are presented in this paper. The complexity of the area requires a combination of various data such as Landsat satellite images, digital elevation model, digital orthophotos as well as existing topographic and thematic maps. The maximum likelihood algorithm was used as the main classifier and the accuracy of results was further improved by fuzzy classification, altitude and inclination filtering and auxiliary data integration.